For consumers prioritizing therapeutic benefits over psychoactive effects, cannabis strains with a higher CBD (cannabidiol) to THC (tetrahydrocannabinol) ratio have become an essential part of the wellness conversation. CBD-dominant strains offer relief for anxiety, inflammation, chronic pain, and seizures without the intense “high” typically associated with THC. As more consumers seek out functional cannabis experiences—especially beginners, medical patients, and those sensitive to THC—selecting the right high-CBD strain is key.
Here’s a curated list of the most recommended high-CBD strains according to industry experts.
Charlotte’s Web
CBD: ~17% | THC: <0.3%
Charlotte’s Web is perhaps the most well-known high-CBD strain, originally developed for pediatric seizure patients. Named after Charlotte Figi, a young girl whose life was changed by CBD therapy, this strain delivers little to no psychoactivity while offering substantial calming and anti-inflammatory properties. It’s widely used for epilepsy, anxiety, and general wellness.
Why it’s recommended: Its extremely low THC content makes it ideal for users seeking a completely non-intoxicating cannabis experience.
ACDC
CBD: ~14–20% | THC: ~1–6%
ACDC is a phenotype of the CBD-rich strain Cannatonic and offers a nearly 20:1 CBD to THC ratio. This sativa-leaning hybrid is known for promoting relaxation, focus, and mood stabilization, making it popular among consumers dealing with stress, nerve pain, and PTSD.
Why it’s recommended: ACDC provides therapeutic effects without the foggy head or high associated with traditional cannabis, making it suitable for daytime use.
Harlequin
CBD: ~8–16% | THC: ~4–7%
Harlequin is a 75/25 sativa-dominant hybrid that typically carries a 2:1 or 5:2 CBD to THC ratio. Its balanced profile results in mild euphoria with noticeable therapeutic effects. It’s often chosen for anxiety, chronic pain, and mild depression.
Why it’s recommended: Harlequin offers a gentle uplift in mood without overwhelming psychoactive effects, ideal for first-timers or those transitioning away from high-THC products.
Ringo’s Gift
CBD: ~10–20% | THC: ~1%
Named after CBD advocate and activist Lawrence Ringo, this hybrid crosses Harle-Tsu and ACDC. Ringo’s Gift comes in multiple ratios, some even reaching 24:1 CBD to THC. It offers a calm, focused, and clear-headed experience often used for inflammation, arthritis, and anxiety disorders.
Why it’s recommended: This strain is a favorite among medical patients who require high CBD potency for chronic conditions without sacrificing mental clarity.
Sweet and Sour Widow
CBD: ~5–11% | THC: ~5–10%
A 1:1 ratio strain created by CBD Crew, Sweet and Sour Widow offers a balanced effect profile. It’s an indica-dominant hybrid that provides light body relaxation paired with mood elevation. It’s used for moderate pain relief, anxiety, and sleep support.
Why it’s recommended: With an equal balance of CBD and THC, this strain is helpful for those looking to ease into psychoactive effects while still receiving therapeutic relief.
Harle-Tsu
CBD: ~18–22% | THC: <1%
A cross between Harlequin and Sour Tsunami, Harle-Tsu is a powerful anti-inflammatory strain without any meaningful intoxication. It has earned multiple awards at the Emerald Cup and is especially popular for pain, migraines, and inflammation.
Why it’s recommended: The strong CBD content combined with minimal THC makes Harle-Tsu one of the most effective non-psychoactive medicinal cannabis strains available.
Why CBD-Dominant Strains Matter
Strains with high CBD-to-THC ratios are in demand for their versatility and safety profile. CBD is non-intoxicating and interacts with the body’s endocannabinoid system to promote homeostasis, making it an attractive option for those seeking:
- Relief from anxiety or depression
- Reduction of seizure activity
- Anti-inflammatory and pain management support
- Focus and clarity without feeling “high”
Many users report better sleep, fewer mood swings, and improved cognitive function with high-CBD strains.
These strains are often recommended by healthcare professionals and cannabis consultants for both new and experienced users looking to manage specific health goals without the potential side effects of THC-heavy options.
In Summary
Whether managing chronic conditions or simply exploring cannabis for general wellness, CBD-rich strains offer a balanced and therapeutic alternative. With reliable genetics and lab-tested profiles, strains like Charlotte’s Web, Harlequin, and Ringo’s Gift continue to lead the industry in efficacy and accessibility.
Always consult with a healthcare provider before starting any cannabis-based regimen, especially if you’re managing a medical condition or taking other medications.